中性粒细胞／淋巴细胞比率与阿尔茨海默病关系的研究

摘要

目的：探讨中性粒细胞／淋巴细胞比率（NLR）与阿尔茨海默病（AD）的关系。方法：收集入住华北理工大学附属医院神经内二科的 AD 患者62例（AD 组）及无认知功能障碍者49例（对照组），采用 Logistic 回归分析 NLR 与AD 的关系。结果：与对照组比较，AD 组 NLR 明显升高，差异有统计学意义（P ＜0.01）。采用 Logistic 回归分析校正了高血压、年龄、受教育史、饮酒史等混杂因素后，AD 组 NLR 升高（OR：5.328，95％ CI：1.497～18.967，P ＝0.010）。结论：NLR 升高是 AD 的危险因素，早期 AD 患者与无认知障碍者相比具有更高的 NLR，升高的 NLR 经常考虑为炎性反应指标。结果提示炎性反应在 AD 发病过程中发挥重要作用。%Objective To explore the relationship between Neutrophil lymphocyte ratio and Alzheimer disease.Method 62 AD patients and 49 patients with normal cognitive function in the second nerval medical department ward of North China Universi-ty of science and technology University Hospital were selected.Relation between NLR and AD was analyzed by logistic regression analysis.Results The NLR of AD patients was significantly higher than that of patients with normal cognitive function(P <0.01).Logistic regression analysis (adjusted for hypertension、age、education、drinking )showed that elevated NLR (OR:5.328,95%CI:1.497 ~18.967,P =0.010)was an independent variable for predicting AD.Conclusion The evaluation of Neutrophil lym-phocyte ratio is a risk factor for Alzheimer disease.Elderly people with AD have higher NLR than healthy controls.Elevated NLR levels are usually considered as an inflammatory marker.The results of this study suggested that inflammation plays a role in the pathogenesis of AD.