目的：观察辅酶Q10对扩张型心肌病（DCM）患者心功能、心室重构及预后的影响，探讨其治疗DCM的机制。方法：选取就诊的100例DCM患者，均接受基础治疗。并按随机数字表法分为观察组52例和对照组48例。观察组加辅酶Q10，随访3个月后观察治疗的有效率、左心室射血分数（LVEF）、左心室收缩末期容积（LVDS）、左心室舒张末期容积（LVDD）、血浆脑钠肽前体（NT－proBNP）的变化。结果：与对照组比较，观察组的临床疗效显效率和总有效率均较高， LVEF上升，差异有统计学意义（P＜0.01），而LVDD与LVDS缩小、NT－proBNP水平明显下降，差异有统计学意义（P＜0.05）。结论：在传统疗法治疗DCM患者基础上，口服常规剂量的辅酶Q10可提高临床疗效。%Objective To found the Coenzyme Q10 treatment′s efficacy in patients with dilated cardiomyopathy(DCM). Meth-od A total of 100 patients of dilated cardiomyopathy were selected.According to random number table method,100 cases were di-vided into experimental group 52 cases and control group each 48 cases;patients in both groups treatment were on the basis of con-ventional treatment methods.Coenzyme Q10 were given in the experimental group.Left ventricular ejection vraction (LVEF),Left ventricular diastolic dimension (LVDD),Left ventricular end-systolic dimension (LVDS),Plasma amino-terminal pro-Brain natriuretic peptide (NT-proBNP)level were observed before and after three months treatment.Results Compared with control group,the dilated cardiomyopathy patients′LVEF was obviously improved,the different was statistically significant (P<0.01 ), LVDD,LVDS and NT-proBNP level also decreased at 3 months compared with that in observation group,the different was statisti-cally significant (P<0.05).Conclusion In additional to the conventional therapy on DCMpatients,oral regular doses of Coenzyme Q10 can improve therapeutic efficacy.
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