通络驻景丸治疗糖尿病视神经病变理论发微

摘要

The composition of Tongluo Zhujing pill derives from ancient prescription Zhujing pill,and its main function is performed by nourishing liver and kidney, eliminating phlegm and removing blood stasis, and activating channels of eyes to improve eyesight.The main pathogenesis of diabetic optic neuropathy is yin deficiency with blood stasis, and should be treated by invigorating the kidney and nourishing yin, and promoting blood circulation and removing blood stasis,which is exactly consistent with the function of Tongluo Zhujing pill.Primary clinical trials have shown that Tongluo Zhujing pilll has exact therapeutic effectiveness on diabetic reti-nopathy,especially on non-proliferative diabetic retinopathy (NPDR). It can improve eyesight and alleviate pathological changes of retina without toxic and side effect. And the animal studies have proved that Tongluo Zhujing pill has the effects of antioxidation and inhibiting the expression of retinal nuclear factor-kB (NF-kB), which can effectively control the development of diabetic retinopathy.%通络驻景丸由古方驻景丸加减化裁而成,旨在补益肝肾、祛痰化瘀、通络明目.从糖尿病视神经病变的病因病机角度探讨可知通络驻景丸治疗机制与糖尿病视神经病变的主要病机阴虚血瘀证型相对应,其治疗原则是在养阴补肾的同时兼以除瘀通络、活血化瘀.在前期临床观察中已证实通络驻景丸的确切疗效,其对于非增殖型糖尿病视网膜病变患者的视力、眼底体征均有明显改善,且安全有效,无毒副作用.同时,通络驻景丸的实验研究也取得重要研究成果,证实本方具有抗氧化功效,能够逆转糖尿病代谢记忆所致的氧化应激反应,且能够抑制视网膜核因子-kB(NF-kB)的高表达,从而有效控制病情发展.