目的 评价依帕司他与甲钴胺联合应用治疗糖尿病周围神经病变的疗效与安全性.方法 检索CNKI数据库,收集以依帕司他与甲钴胺联合应用为干预措施治疗糖尿病周围神经病变的随机对照研究.对纳入的研究文献进行方法学质量评价,提取有效数据进行Meta分析.结果 共纳入6个随机对照研究,共纳入糖尿病周围神经病变患者496例.试验组为基础治疗加依帕司他与甲钴胺联合应用,对照组为基础治疗加B族维生素.Meta分析结果显示,试验组在改善糖尿病周围神经病变患者的临床症状的有效率方面优于对照组(P＜0.01,OR=3.58,95％CI=2.26-5.66).结论 依帕司他与甲钻胺联合应用对糖尿病周围神经病变患者的临床症状有改善作用.%Objective To evaluate the efficacy and safety of epalrestat combined with methylcobalamin in treating diabetic peripheral neuropathy. Methods The electronic databases CNKI was searched to collect the randomized controlled trials of epalrestat combined with methylcobalamin for the treatment of diabetic peripheral neuropathy. The methodological quality of the trials was evaluated and the valid data for Meta-analysis were extracted. Results Six randomized controlled trials(496 cases) were included. In addition to conventional basic treatments, test group was treated with additional epalrestat combined with methylcobalamin, while control group was treated with additional B vitamins. Meta analysis showed that the patients in test group was better than those in control group in the improvement of clinical symptoms(P<0. 01,OR=3. 58,95%CI=2. 26-5. 66). Conclusion The Meta analysis on this group shows that epalrestat combined with methylcobalamin can improve the clinical symptoms in the patients with diabetic peripheral neuropathy.
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