糖尿病患者合并下呼吸道感染的临床特点与危险因素分析

摘要

Objective To investigate the clinical characteristics and risk factors for complicating lower respiratory tract infection(LRTI) in diabetic patients.Methods A total of 403 patients with type 2 diabetes mellitus(T2DM) was assigned into two groups of A(203 cases with LRTI) and B(200 cases without LRTI).The diabetic clinical characteristics and risk factors for LRTI were analyzed.Results The patients in group A were with fever in 66.50％ (135/203),cough and expectoration in 51.23％(104/203) The pathogen-positive rate in sputum culture was 80.30％,in which the gramnegative bacteria accounted for 71.78％.Multifactor unconditioned Logistic regression analysis showed that the aging,poor control of blood sugar,decreased lung ventilation function,hypoproteinemia,elevated blood β2-MG were the independent risk factors for the T2DM patients to complicating LRTI(P＜0.05).Conclusion The pathogens in the T2DM patients complicating LRTI are mainly gram-negative bacteria.The aging,poor control of blood sugar,decreased lung ventilation function,hypoproteinemia,elevated blood β2-MG are the independent risk factors for LRTI.%目的 探讨糖尿病合并下呼吸道感染(LRTI)患者的临床特点及危险因素.方法 403例2型糖尿病(T2DM)患者分为合并LRTI(A组,203例)和无LRTI(B组,200例)两组,分析糖尿病合并LRT1的临床特点及危险因素.结果 A组患者发热为主者占66.50％ (135/203)、伴有咳嗽咳痰占51.23％(104/203);痰液病原菌培养阳性率80.30％(革兰氏阴性菌占71.78％).多因素非条件Logistic回归分析显示,患者年龄大、血糖控制不良、肺通气功能不良、低蛋白血症、血β2微球蛋白(β2-MG)升高是引起糖尿病患者合并有LRTI发生的独立危险因素(P＜0.05).结论 糖尿病合并LRTI病原菌以革兰氏阴性菌为主；患者年龄大、血糖控制不良、肺通气功能不良、低蛋白血症和血β2-MG升高是引起患者发生LRTI的主要危险因素.