目的：探讨胃癌组织中血小板源性生长因子受体（PDGFR）和核因子κB（NF‐κB）的表达与胃癌临床病理特征及预后的关系。方法收集183例胃癌组织、癌旁组织和30例正常胃黏膜组织标本，用免疫组化方法检测PDGFR和NF‐κB表达，分析其与胃癌临床病理特征及患者预后的关系。结果胃癌组织 PDGFR和 NF‐κB的表达均明显高于癌旁组织和正常胃黏膜。胃癌组织PDGER与NF‐κB的高表达均与肿瘤大小、分化程度、浸润深度、有无淋巴结转移以及 TNM 分期密切相关（P＜0．05）。肿瘤大小、浸润深度、淋巴结转移、术后辅助化疗、PDGFR和NF‐κB高表达均是评估胃癌根治术后患者预后的独立因素（P＜0．05）。结论胃癌组织高表达PDGFR与NF‐κB可作为评价胃癌患者预后的指标和临床干预的潜在靶点。%Objective To study the expressions and significance of platelet‐derived growth factor receptor(PDGFR) and nuclear factor‐kappaB (NF‐κB) in gastric carcinoma .Methods With immunohistochemistry ,the expressions of PDGFR and NF‐κB were detected in 183 samples of gastric carcinoma and its tumor‐adjacent tissues and 30 samples of normal gastric mucosal .The relationship of PDGFR and NF‐κB expressions and clinicopathological characteristics and prognosis was analyzed . Results The expressions of PDGFR and NF‐κB were significantly higher in gastric cancer than those in tumor‐adjacent and normal gastric mucosa tissues .High expressions of PDGFR and NF‐κB in gastric carcinoma were closely related with tumor size ,differentiation ,invasive depth ,lymph node metastasis and TNM stage(P<0 .05) .The tumor size ,invasive depth ,lymph node metastasis ,postoperative adjuvant chemotherapy ,and overexpressions of PDGFR and NF‐κB were the independent risk factors for predicting postoperative prognosis of the patients with gastric carcinoma .Conclusion High expressions of PDGFR and NF‐κB in gastric carcinoma may be taken as the indicators for predicting postoperative prognosis and potentonal target for clinical intervention in the patients with gastric carcinoma .
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