Objective To analyze the human papillomavirus (HPV ) infection and its genotype distribution in the 6091 women of gynecologic clinic of a hospital of Nantong .Methods From 2015 to 2017 ,6091 cervical exfoliated cell specimens were collected from women in a hospital gynecologic clinic of Nantong ,which were examined with PCR reverse dot blot for 23 kinds of HPV genotypes .The epidemiological characters were analyzed .Results A total of 1784 HPV positive cases was detected with a HPV infection rate of 29.29% (1784/6091) ,which was 53.45% (31/58) for the age group of<21 years ,48.33% (29/60) for the age group of more than 61 years old .The infection rate of signal HPV genotype was 65.13% (1162/1784) and that of single high risk HPV infection was 50.90%(908/1784) and multiple HPV infection was 34.87% (622/1784) .The infection rate of high risk HPV was 24.78% (1509/6091) and that of low risk HPV was 9.30% (565/6091) .The infection rate of HPV was 57.50% (23/40) in the women with vulvitis ,31.07% (472/1519) in those with cervicitis , and 41.18% (7/17) in those with cervical intraepithelial neoplasia .The top five HPV genotypes were 52 ,16 ,58 ,81 and 53 .Conclusion The overall infection rate of HPV is 29.29% for the women in gynecologic clinic of a hospital of Nantong .Single high risk HPV infection is the most common type . The women aged <21 years old and more than 61 years old are sensitive to HPV infection .The most popular HPV genotypes are HPV 52 ,16 ,58 ,81 and 53 .%目的 分析南通市某医院妇科门诊女性H PV感染及其基因型分布.方法 收集南通市某医院2015—2017年妇科门诊6091例女性宫颈脱落细胞标本,采用PCR-反向点杂交法对23种H PV基因型进行检测,并分析其流行病学特点.结果 6091例就诊女性中共检测出1784例感染者,阳性率为29.29%(1784/6091).<21岁组感染率为53.45%(31/58),61岁~组感染率为48.33%(29/60).单一型感染率为65.13%(1162/1784),其中,单一高危型的感染率为50.90%(908/1784),多重感染率为34.87%(622/1784).高危型H PV总的感染率为24.78%(1509/6091),低危型为9.30%(565/6091).外阴炎、宫颈炎和宫颈上皮内瘤变患者的H PV感染率分别为57.50%(23/40)、31.07%(472/1519)和41.18%(7/17).HPV感染最高的前5位基因型分别为52型、16型、58型、81型和53型.结论 该院门诊女性HPV的感染率为29.29%,以单一高危型感染为主,<21岁和61岁~为两个感染高峰年龄段.H PV 52型、16型、58型、81型和53型为主要的感染亚型.
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