中性粒细胞比例评估系统性红斑狼疮病情的应用价值

摘要

Objective To explore the value of the proportion of neutrophils in peripheral blood in evaluating the illness staus of systemic lupus erythematosus(SLE).Methods The neutrophil counts and the proportion of neutrophils in peripheral blood were detected in 27 SLE patients(group A)and 81 healthy people(group B).The relationship of the proportion of neutrophils with lupus nephritis and lupus activity was analyzed.Results The proportion of neutrophils was higher in group A than that in group B[(66.29 ± 12.00)% vs.(57.08 ± 8.05)%](P<0.01),which was not significantly different in the neutrophil counts between two groups(P>0.05).The neutrophil counts and the proportion of neutrophils were higher in SLE patients with lupus nephritis than those without lupus nephritis(P<0.05 or P<0.01).The proportion of neutrophils was positively correlated with 24-hour urinary protein(r = 0.382,P<0.05).The sensitivity and specificity of proportion of neutrophils to predict the lupus nephritis were 0.824 and 0.800.The proportion of neutrophils was higher in the patients with severe activity than that in those without severe activity(P<0.01).The proportion of neutrophils was positively correlated with SLE disease activity index score(r= 0.634, P<0.01).The sensitivity and specificity of proportion of neutrophils to predict the lupus activity were 0.846 and 0.643,respectively.Conclusion The proportion of neutrophils is closely associated with the lupus nephritis and lupus activity,which could be used as an indicator for predicting the occurance of lupus nephritis and lupus activity.%目的 探讨外周血中性粒细胞比例评估系统性红斑狼疮(SLE)病情的应用价值.方法 检测27例SLE患者(SLE组)及81例健康体检者(对照组)外周血的中性粒细胞数及其比例,分析中性粒细胞比例与狼疮活动度及狼疮肾炎的关系.结果 SLE组外周血中性粒细胞比例高于对照组[(66.29 ± 12.00)% vs.(57.08 ± 8.05)%](P<0.01),而两组外周血中性粒细胞数差异无统计学意义(P>0.05).SLE组中,狼疮肾炎患者外周血中性粒细胞数及其比例高于无狼疮肾炎患者(P<0.05或P<0.01).中性粒细胞比例与24-h尿蛋白呈正相关(r=0.382,P<0.05),中性粒细胞比例预测狼疮肾炎的灵敏度为0.824,特异度为0.800.狼疮重度活动患者中性粒细胞比例高于非重度活动患者(P<0.01),中性粒细胞比例与 SLE 疾病活动指数评分呈正相关(r= 0.634, P<0.01).中性粒细胞比例预测狼疮重度活动的灵敏度为0.846,特异度为0.643.结论 外周血中性粒细胞比例与狼疮肾炎及狼疮活动度密切相关,可用于预测狼疮肾炎和重度活动的发生.