基质金属蛋白酶表达调控与糖尿病视网膜病变的关系

摘要

The exact molecular mechanism of diabetic retinopathy (DR) remains unclear.Hyper-glycemia in DR can increase the expression of matrix metalloproteinases (MMPs).MMPs are a family of zinc-dependent endopeptidases that can collectively degrade almost all components of the extracellular ma -trix.They are involved in the process of apoptosis and angiogenesis in DR .Their enzymatic activity is tightly regulated under physiological conditions .Primary modes of enzyme regulation include transcriptional control , zymogen activation and tissue inhibitors of MMPs .Among which transcriptional control is the most important regulatory mechanism.(Int Rev Ophthalmol, 2019, 43: 53-57)%糖尿病视网膜病变(diabetic retinopathy,DR)确切的分子机制尚不清楚,高糖环境可致基质金属蛋白酶(matrix metalloproteinases,MMP)表达增加,MMP是一组锌离子依赖的蛋白水解酶,可以降解几乎所有的细胞外基质成分,在DR中参与了细胞凋亡和新生血管生成过程.在正常生理条件下,MMP活性的调节发生在多水平,包括基因转录调控水平、酶原激活、基质金属蛋白酶组织抑制剂调控水平等.其中基因转录水平的调控是最主要的调控机制.