妊娠期肝内胆汁淤积症发病机制的免疫学研究进展

摘要

妊娠期肝内胆汁淤积症(ICP)对母婴尤其是胎儿安全构成风险.尽管目前研究较广泛,但ICP发病机制仍然不明确.ICP患者胆汁酸增加可能与免疫系统的多方面变化有关.此文从孕妇免疫系统变化角度对ICP患者发病机制进行综述,以了解免疫系统改变对ICP发生发展的作用机制.%Intrahepatic cholestasis during pregnancy (ICP) poses a great risk to both maternal and fetal health. Despite of extensive research, the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis during pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this paper, we have reviewed the pathogenesis of ICP patients from the perspective of changes in the immune system of pregnant women to understand the role of immune system changes on the pathogenesis of ICP.