脑梗死患者急性期TNBNP与CRP浓度的变化及临床意义

摘要

目的 探讨血浆脑钠肽前体(NTBNP)与C-反应蛋白(CRP)在脑梗死中的表达及其临床意义.方法 应用酶联免疫分析法测定40例脑梗死急性期患者和40例亚急期患者血浆NTBNP与CRP浓度,并以30例健康自愿体检者作对照.结果 脑梗死组急性期血浆NTBNP、CRP含量显著高于亚急性期(P<0.01),且两者与正常埘照组相比,差异有极显著性(P<0.01),大面积脑梗夕匕组血浆BNP、CRP含最显著高于非大面积脑梗死组(P<0.01).结论 脑梗死患者急性期血浆NTBNP和CRP水平明显升高,提示二者在脑梗死的发病过程中起重要作用.%Objective To explore the changes of plasma levels of NTBNP and CRP in patients with acute cerebral infarction and its possible pathophysiologic implications.Method* The level of plasma NTBNP and CRP of 40 patients with acute cerebral infarction,40 patients with subacute cerebral infarction and 30 healthy controls were determined by ELISA.Results The levels of NTBNP and CRP of patients with acute cerebral infarction were significantly higher than those in control and subacute cerebral infarction groups(P<0.01), and the plasma of NTBNP and CRP in patients with large area of infarction were significantly higher than those in patients with small area of infarction(P<0.01).Conclusions Plasma NTBNP and CRP are increased significantly in patients with cerebral infarction,they possibly play the most important key role in the pathogenesis of cerebral infarction.