Objective To study the renal protection of aminophylline on neonates with asphyxia. Methods 52 neonates with perinatal asphyxia were random divided into experimental group (27 cases) that receive a single dose aminophylline (5mg/kg,) intervenous drop infusion and control group (25 cases) that reveived aqua proinjectione intervenous drop infusion during the first hour of life. The urinary excretion beta 2 micr- oglobulin ( β 2M) was detected for consecutive three days after birth in neonates with asphyxia. Data from two groups were analyzed by statistics.Results There was no statistically significance difference in the levels of β 2 M at 24 hours and 48 hour after birth ( P < 0.05 ) but a statistical significance of 72h after birth (P < 0.01 ) between the experiental group and control group.Conclusios A single dose of aminophylline ( 5mg/kg ) within the first hour of birth in neonates with perinatal asphyxia results in a significant decrease in urinary excretion of β2M.%目的 本研究通过窒息新生儿生后3天尿β2微球蛋白的变化,探讨氨茶碱对窒息新生儿肾脏的保护作用.方法 52例窒息新生儿随机分为试验组和对照组.分别在生后1小时内静脉滴注氨茶碱(5mg/kg)和注射用水,测定两组新生儿生后24h、48h、72h尿β2微球蛋白值.对比两组的差异.结果 (1)试验组与对照组不同时间尿β2微球蛋白的变化,差异有统计学意义(P=0.048).(2)试验组与对照组同一时间的尿β2微球蛋白生后24h、48h对比,差异无统计学意义(P=0.234,0.196),生后72h差异显著(P=0.001).结论 新生儿窒息时,腺苷分泌增多引起肾血管收缩,而氨茶碱作为腺苷受体阻滞剂,能改善肾血流,使尿β2微球蛋白水平降低.提示氨茶碱临床用药有效,是窒息新生儿肾损伤的有效治疗手段.
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