目的 采用病例对照研究的方法探讨先天性心脏病与环境因素的关系.方法 选取在2006年1月至2009年12月在本院住院的先天性心脏病患儿54例作观察组,并随机抽取同期再本院出生的正常足月儿66例作对照组,对与先天性心脏病的发生可能有关的因素作多项分类Logistic回归模型分析.结果 母亲孕期在鞋厂工作(或销售)、母亲孕期患病毒感染性疾病均与婴幼儿先天性心脏病的发病显著相关(x2=14.906,P＜0.01;x2=5.136,P＜0.05).结论 先天性心脏病的发生与母亲孕期在鞋厂工作(或销售)及母亲孕期患病毒感染性疾病可能有关.%Objective A case-control study was carried out to explore the relationship between environmental pollution and congenital heart disease. Methods Selected 54 cases with congenital heart disease from the inpatients in our hospital as a study group, during January 2006 to October 2009;and randomly select 66 cases normal infants as a normal control group. Used Unconditional Logistic model to control confounding and estimate the relative risk. Results The monthers work in the shoes factory during pregnant and the mothers have virus infected disease during pregnant, have high possibility to born a baby with congenital heart disease( x2=14.906, P＜ 0.01; x2=5.136, P ＜ 0.05).Conclusions it suggested that environmental pollution caused by the works of shoes factory and infection with virus during pregnant are risk facters for congenital heart disease.
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