早期重症乙型肝炎和肝硬化凝血酶原活动度改变意义

摘要

Objective To investigate the relationship between the changes of prothrombin activity (PTA) and early severe hepatitis and cirrhosis in the patients.Methods The method of random sampling was used,a retrospective analysis on PTA was carried out in the patients with severe hepatitis and cirrhosis in hepatology section in our hospital from January to December in 2010.Results PTA(％)of general acute hepatitis was higher than early severe hepatitis and cirrhosis ( P ＜ 0.01 ); PTA ( ％ ) of early severe hepatitis was lower than that of the cirrhosis group (P＜ 0.05 ); PTA ( ％ ) ＜ 30 or ＞ 30,the case fatality rate of severe hepatitis was higher than that of cirrhosis,the differences were statistically significant (P ＜ 0.05); the case -fatality rate of early diagnosis and treatment was lower than advanced diagnosis and treatment on severe hepatitis (x 2=5.21,P ＜ 0.05 ).Conclusion PTA is a sensitive index on reflection of early severe hepatitis and liver cirrhosis; suggestion of dynamic monitoring on PTA should be used for patients with hepatitis B,if patients of early severe hepatitis and cirrhosis can be found,and reasonable treatment can be provided,then the death rate would be reduced.%目的 探讨早期重症乙型肝炎和肝硬化患者病情和凝血酶原活动度(PTA)改变之间的关系.方法 采用单纯随机抽样方法,对2010年1月至2010年12月本院肝病科部分住院重症乙型肝炎和肝硬化病人的PTA做了回顾性分析.结果 一般急性肝炎组的PTA(％)比早期重症乙型肝炎组、肝硬化组较高(P＜0.01):早期重症乙型肝炎组的PTA(％)较肝硬化组较低(P＜0.05):PTA(％)＜ 30或者≥30时,重症乙型肝炎组比肝硬化组的病死率均高,差异均有统计学意义(P均＜0.05);早期重症乙型肝炎诊治组的病死率比中晚期重症乙型肝炎诊治组的病死率低(x2=5.21,P＜0.05).结论 PTA是反映早期重症乙型肝炎、肝硬化患者病情的较为灵敏的指标.建议对乙型肝炎患者进行PTA的动态监测,如能发现早期重症乙型肝炎、肝硬化患者,并进行合理诊治,会使患者的病死率降低.