泛福舒对中重度支气管扩张症临床疗效的探讨

摘要

Objective To explor the curative effect of Broncho-Vaxom in patiens of severe and middle bronchiectasis.Methods Total 127 patiens were randomized to two groups, treatment group were receive treatment using Broncho-Vaxom, antibiotic and antasthmatic.Contrl group receive treatment only using antibiotic and antasthmatic .Results The difference of PaO2 ( mmHg ) and SaO2 ( % ) level before treatment was not significant between two groups( P＞0.01 ). The level of PaO2( mmHg ) and SaO2( % ) of treatment group obviously risen up compared to control group ( P＜ 0.01). There were not significant deviation of IgG and IgA level in blood serum before treatment between two groups( P＞0.01 ). The level of IgG and IgA of treatment group obviously risen up compared to control group ( P＜ 0.01 ). The case and probability of palindromia respiratory infection the same as hospital day were obviously lower compared to control group( P＜0.05 ). The positive rate of bacterial culture by BFS of treatment group was lower significantly compared to control group ( P＜ 0.05 ). Conclusion Broneho-Vaxom could regulate immunologic function of body and enhance defence of airway, it can effectively improve the prognosis of severe and middle bronchiectasis patients.%目的 探讨泛福舒胶囊(细菌溶解产物胶囊)对中重度支气管扩张症患者的临床疗效.方法 将127例中重度支气管扩张症患者随机分为治疗组和对照组;对照组在伴发感染时予抗感染、平喘等治疗,治疗组在此基础上加用泛福舒胶囊(细菌溶解产物胶囊),每日晨空腹口服7 mg,连服10 d,停20 d,再连服10 d,停20 d,再连续10 d.连续使用3个月为1个疗程;连用3个疗程,两组均观察9个月,评价治疗前后血气分析PaO2(mmHg)、SaO2(%),血清IgG、IgA水平变化,呼吸道再发感染率(%)、平均住院日数(天)以及细菌刷检培养阳性率(≥103cfu/ml)的变化.结果 两组治疗前PaO2(mmHg)、SaO2(%)对比差异无显著性(P＞0.01),治疗后治疗组PaO2(mmHg)、SaO2(%)明显好于对照组(P＜0.01);两组治疗前血清IgG、IgA对比差异无显著性(P＞0.01),治疗后治疗组血清水平IgA较对照组有明显提高(P＜0.01),而血清中IgG两组无明显变化,均无统计学意义;治疗后呼吸道再发感染率(%),治疗组再发感染的机率明显少于对照组(P＜0.05);治疗后平均住院日数(天)治疗组明显少于对照组(P＜0.05);治疗后纤维支气管镜刷检检查,细菌刷检培养阳性率(≥103cfu/ml),治疗组的阳性率明显低于对照组(P＜0.05).结论 泛福舒胶囊(细菌溶解产物胶囊)能调节机体的免疫功能,提高呼吸道的抵抗力,有效改善中重度支气管扩张症患者的预后.