性别因素对七氟醚增强罗库溴铵肌松效应的影响

摘要

Objective To observe the effect of gender on neuromuscular blockade induced by rocuronium with sevoflurane.Methods 180 elective operation patients divided into two groups according to sex,male group and female group.Divided into 4 subgroups according to random number table,were female sevoflurane group,male sevoflurane group,female propofol group and male propofol group.Propofol group was anesthesiaed with intravenous infusion,infusion of rocuronium after 5 minutes;Sevoflurane group anesthesia with sevoflurane inhalation,intravenous infusion of rocuronium after end-tidal sevoflurane concentration stability.Comparing the 4 groups of patients with onset time,complete muscle relaxation time,T1 recovered to 25％ and recovery of 90％.Results There were no significant difference between 4 groups.Comparison of female patients between male patients in propofol group,onset time of female patients was shorter than male patients.Complete muscle relaxation time,recovered time ofT1 to 25％ and 90％ was more than male patients,there was significant difference(P ＜ 0.05).Comparison of female patients between male patients in sevoflurane group,female group recovered time of T1 to 25％ and 90％ was longer than male patients,there was significant difference(P＜ 0.05).The recovered time of T1 to 90％ in female sevoflurane group was longer than female propofol group,there was significant difference(P ＜ 0.05).Male sevoflurane group has short time of onset time,more longer complete muscle relaxation time,T1 recovered to 25％ and 90％ than male propofol group,there was significant difference(P ＜ 0.05).Conclusion Gender factors have a significant effect on neuromuscular blockade induced by rocuronium with sevoflurane,males are more obvious.%目的 探讨性别因素对七氟醚增强罗库溴铵肌松效应产生的影响.方法 以丙泊酚作为对照,选择我院收治的手术患者180例,按性别不同随分为4个亚组.丙泊酚组:静脉输注丙泊酚,5 min后输注罗库溴铵;七氟醚组:吸入七氟醚,七氟醚浓度稳定后静脉输注罗库溴铵.比较4组患者肌松起效时间、完全肌松时间、T1恢复到25％和90％的时间.结果 4组患者的一般资料具有均衡性.丙泊酚组女性患者较男性患者肌松效应起效时间更短,完全肌松时间、25％恢复时间、90％恢复时间更长,差异有统计学意义(P＜0.05).七氟醚组女性患者较男性肌松效应起效时间更短,完全肌松时间、T1恢复到25％恢复时间和90％恢复时间更长,差异有统计学意义(P＜0.05).女七氟醚组较女丙泊酚组90％恢复时间更长,差异有统计学意义(P＜0.05).男七氟醚组较男丙泊酚组起效时间更短,完全肌松时间、25％恢复时间、90％恢复时间更长,差异有统计学意义(P＜0.05).结论 男性患者七氟醚增强罗库溴铵肌松的作用效果强于女性,且男性患者七氟醚增强罗库溴铵肌松的作用比丙泊酚更为显著,性别因素对七氟醚增强罗库溴铵肌松效应产生明显的影响.