佛山市三水区正常人群血锰本底值水平的研究

摘要

目的 了解广东省佛山市三水区正常人群体内血锰(Mn)的本底值水平,评价其对正常人群健康的影响,为中毒原因的调查及疾病的辅助诊断、防控重金属污染提供科学依据.方法 采用多阶段分层整群随机抽样的方法,于2009年10月至2010年4月抽取6岁以上非职业接触化学因素的正常人共804人,采集全血样本,采用离子耦合质谱法(ICP-MS)检测.结果 正常人群中血Mn参考范围为5.89～18.18 μg/L,均值为(11.36±3.59)μg/L;血Mn浓度水平以16～岁组最高,30～岁组最低;女性血Mn浓度水平高于男性.结论 三水地区正常人群体内血Mn的本底值水平较高,年龄和性别之间存在差异.这可能与实验室间差异、人群饮食结构和环境Mn负荷有关,需要进一步调查研究,提示该地区应重视重金属污染的预防控制.%Objective To understand blood manganese(Mn)background value level in general population at Sanshui district of Foshan,Guangdong province,to assess the effect of manganese on health in these people,and to provide support for screening poisoning causes,disease diagnosis,and prevention and control of heavy metal pollution.Methods Multistage stratified cluster random sampling was used.Blood samples were collected from 804 people older than 6 with non-professional exposure to chemical factors during the period of October 2009 to April 2010.Ion coupling mass spectrometry(ICP-MS)was applied for detection.Results The normal blood Mn reference value ranged from 5.89 to 18.18 μg/L,with a mean value of(11.36±3.59)μg/I;Blood Mn concentration was highest in the group of older than 16 and lowest in the group of older than 30.Blood Mn level was higher in females than in males.Conclusions General population at Sanshui district has a higher level of blood Mn background value;and the value differs in age and sex.The reason why is that may be associated with difference among labs,dietary differences,and environmental Mn loads.It suggests that further research is needed and prevention and control of heavy metal pollution at Sanshui district should be strengthened.