前列地尔对慢性阻塞性肺疾病急性加重期的疗效研究

摘要

Objective To observe the effect of alprostadil injection for chronic obstructive pulmonary disease in acute exacerbation period.Methods Seventy-eight cases of chronic obstructive pulmonary disease in acute exacerbation period were randomly divided into a treatment and a control group.The control group received conventional medicine treatment.In addition,the treatment group treated with alprostadil injection.Both groups' patients were monitored.Results The total effective rate was 89.74％ in the treatment group and was 76.92％ in the control group,with a statistical difference (P＜0.05).The blood rheology and blood gas analysis were btter and the levels of CRP,TNF-α,and IL-8 and the pulmonary artery pressure were significantly lower in the treatment group than in the control group (P＜0.05,P＜0.01).Conclusion Conventional therapy combined with alprostadil injection for chronic obstructive pulmonary disease in acute exacerbation period has better clinical efficacy.Its mechanism may lie in the expansion of blood vessels,inhibition of platelet aggregation,reducing blood viscosity,improving erythrocyte deformation ability and blood rheology.%目的 观察前列地尔注射液治疗慢性阻塞性肺疾病急性加重期的临床疗效.方法 将78例慢性阻塞性肺疾病急性加重期患者随机分为前列地尔治疗组和对照组,对照组采用常规内科综合治疗,治疗组在对照组治疗的基础上加用前列地尔注射液静脉注射,监测两组患者.结果 治疗组总有效率为89.74％,明显优于对照组76.92％ (P＜0.05),治疗组在改善血液流变学、血气分析方面明显优于对照组(P＜0.05),且能显著降低CRP、TNF-α、IL-8含量(P＜0.01),明显降低肺动脉压(P＜0.01).结论 慢性阻塞性肺疾病急性加重期在常规治疗的基础上加用前列地尔注射液有较好的临床疗效,其作用机制可能在于通过扩血管作用抑制血小板凝集、降低血黏度和改善红细胞的变形能力,改善血液流变学.