血尿酸水平对原发性高血压患者血清高敏C反应蛋白水平、血压变异性的影响

摘要

Objective To observed and analyze the effects of blood uric acid (BUA) level on the levels of serum high sensitive C-reactive protein (hs-CRP),blood pressure variability (BPV) of the patients with essential hypertension (EH).Methods 160 cases of EH patients were selected as the research objects and divided into four groups according to the four quartiles of the BUA:the 1st quartile group (BUA ≤ 464.93 μ mmol/L),the 2nd quartile group (464.93 μ mmol/L ＜BUA ≤ 508.27 μ mmol/L),the 3rd quartile group (508.27 μ mmol/L ＜BUA ≤ 607.31 μ mmol/L),the 4th quartile group (BUA ＞ 607.31 μ mmol/L).40 patients were included into each group.24h blood pressure monitoring was conducted to the patients in the four groups and the levels of hs-CRP of the patients were detected and compared.Results There were no significant differences of the mean blood pressure at every period among the patients in the four groups (P ＞ 0.05).The night SBPSD and DBP-SD of the patients in the 4th quartile group were significantly higher than those of the 3rd quartile group (P ＜ 0.05) and the SD of the 3rd quartile group was significantly higher than that of the 1st or 2nd quartile group (P ＜ 0.05); the serum hs-CRP levels of the patients in the four groups were in ascending order and there were significant differences between the groups (P ＜ 0.05); the multiple linear regression analysis showed,the night SBP-SD (β =0.293,P ＜ 0.05) and hs-CRP (β =0.627,P ＜ 0.05) were independent factors associated with BUA level.Conclusion BPV and serum hs-CRP level can reflect the organ damage of the patients with EH.BPV and hs-CRP levels are correlated with the level of BUA in patients with EH and can be used as the reference indicators of renal artery injury of the patients with EH.%目的 观察和分析血尿酸(BUA)水平对原发性高血压(EH)患者血清高敏C反应蛋白水平(hs-CRP)、血压变异性(BPV)的影响.方法 选取160例EH患者作为研究对象,根据其BUA水平的四分位数值将其分为四组:第1四分位组(BUA≤464.93 μ mol/L)、第2四分位组(464.93μmol/L＜ BUA≤508.27μmol/L)、第3四分位组(508.27μmol/L＜BUA≤607.31μmol/L)、第4四分位组(BUA＞607.31μmol/L),每组各40例患者.对四组患者的血压情况进行24 h监测,并对患者的hs-CRP水平进行检测和比较.结果 四组患者的各时段血压均值无显著性差异(P＞0.05),而第4四分位组患者的夜间SBP和DBP的SD值显著高于第3四分位组(P＜0.05),第3四分位组显著高于第1、2四分位组(P＜0.05);四组患者的hs-CRP水平依次上升,且各组之间的差异均有显著性(P＜0.05);多元线性回归分析结果显示,夜间SBP-SD(β=0.293,P＜0.05)和hs-CRP水平(β=0.627,P＜ 0.05)都是BUA水平的独立相关因素.结论 BPV和血清hs-CRP水平可反映EH患者的器官受损情况,BPV和hs-CRP水平都与患者BUA水平具有相关性,可作为提示EH患者肾脏动脉损伤情况的参考指标.