Objective To understand the clinical symptoms and treatment method of acute schizophrenia,to explore the effect of antipsychotic drugs on the social function recovery in acute phase schizophrenia patients.Methods In our hospital from 2010 June to 2013 June,we treated 45 cases of the acute phase of schizophrenia patients as the research object.By using the method of random with the intention we divided them into three groups,15 cases in each group.Among them,group A was treated with anti psychotic drugs typical,group B was treated with atypical antipsychotic drugs for treatment,group C used paliperidone extended-release tablets for treatment,and then used the personal and social performance scale (PSP) and positive and negative symptom scale (PANSS) on the treatment of three groups of patients before treatment,4 weeks,12 weeks and 24 weeks after treatment,we evaluated the social function,then carried on the contrast analysis.Results After the analysis,we compared three groups of patients before and after treatment,the PANSS score had significant statistical difference (P ＜ 0.01),and in group C patients after 4 weeks,the PANSS scores (with the exception of positive symptom score) were significantly lower than those in group A and group B,showing a significant statistical difference (P ＜ 0.05),and 12 weeks and 24 weeks later,in group B and C,the PANSS scores (with the exception of positive symptom score) were significantly lower than those of group A,showing significant statistical difference (P ＜ 0.05); the three groups before and after treatment PSP scores showed significant statistical difference (P ＜ 0.01),but for PSP score,the treatment group A after treatment for 12 weeks and 24 weeks ago there was no significant statistical difference (P ＞ 0.05),the group C at 4 weeks after treatment PSP score was significantly higher than that of group A and B group,after treatment for 12 weeks and 24 weeks in the group B the PSP score was higher than that in group A,group C,PSP scores were significantly higher than that in group B,showing significant statistical difference (P ＜ 0.05).Conclusions Antipsychotic drugs can improve the social function of acute phase patients with schizophrenia,but from the effects of view,atypical antipsychotics are better than typical antipsychotic drugs,especially with paliperidone extended-release tablets optimal.But the influencing factors during the acute phase of the social function of schizophrenia patients recovery is relatively complex,so the drug of choice for patients with acute schizophrenia for the social function recovery has very big impact,therefore,clinical attention should be emphasized.%目的 了解急性期精神分裂症的临床症状和治疗方法,探讨抗精神病药物对急性期精神分裂症患者社会功能恢复的影响.方法 选择我院2010年6月至2013年6月收治的45例急性期精神分裂症患者作为研究对象.采用随机结合患者意愿的方法将患者三组,每组1 5例.其中,A组使用典型的抗精神病药物治疗,B组使用非典型的抗精神病药物进行治疗,C组使用帕利哌酮缓释片进行治疗,然后使用个人与社会表现量表(PSP),阳性与阴性症状量表(PANSS)对三组患者治疗前,治疗后4周,12周,24周的社会功能进行评价,然后进行对比分析.结果 经过分析显示,治疗前后,三组患者的PANSS评分比较差异有统计学意义(P＜0.01),而C组患者治疗后4周的PANSS评分(阳性症状评分除外)皆显著低于A组和B组,相比差异有统计学意义(P＜0.05),同时B组和C组治疗后12周,24周的PANSS评分(阳性症状评分除外)均显著低于A组,相比差异有统计学意义(P＜0.05);三组治疗前后的PSP评分相比差异有统计学意义(P＜0.01),但A组治疗后12周和24周的PSP评分与治疗前相比差异无统计学意义(P＞0.05),C组在治疗后4周的PSP评分显著高于A组和B组,治疗后12周和24周B组的PSP评分显著高于A组,C组的PSP评分显著高于B组,相比差异有统计学意义(P＜0.05).结论 抗精神病药物能够改善急性期精神分裂症患者的社会功能,但是从药效上看,非典型抗精神病药物优于典型抗精神病药物,尤其以帕利哌酮缓释片最优.但影响急性期精神分裂症患者社会功能恢复的因素比较复杂,因此药物选择对于急性期精神分裂症患者的社会功能恢复影响非常大,因此临床应予以注意.
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