神经节苷脂联合早期康复治疗急性脑梗死的临床研究

摘要

目的 探讨神经节苷脂联合早期康复治疗急性脑梗死(ACI)的临床疗效.方法 收集首次发病的ACI患者120例,并按入院时间顺序采用完全随机法分为三组(对照A组、对照B组、研究组),每组各40例,对照A组采取康复治疗干预,对照B组采用神经节苷脂治疗,研究组予以神经节苷脂治疗的同时进行积极的康复治疗,并于治疗前及治疗后采用美国国立卫生研究院卒中量表评分标准(NIHSS)、简式Fugl-Meyer运动功能积分(FMA)及修订的Barthel指数(BI)评定所有患者的神经功能、肢体运动功能及ADL的变化,并进行临床疗效评定.结果 三组患者治疗4周后的NIHSS、FMA及ADL评分均较治疗前明显升高,且差异有统计学意义(P＜0.05),其中研究组明显较对照A、B组高(P＜0.05);临床疗效比较:研究组的痊愈率及总有效率均明显高于对照A、B组(P＜0.05).结论 神经节苷脂联合早期康复治疗可明显促进ACI患者恢复肢体运动功能,改善神经功能缺损水平及提高ADL,是进一步优化提升脑梗死临床治疗手段的重要思路.%Objective To discuss the clinical efficacy of the ganglioside combined with early rehabilitation in treatment for acute cerebral infarction (ACI).Methods We collected 120 patients with the ACI who were all in the first onset,and were completely randomly divided into three groups according to the admission chronological order (Control group A,the control group B,the study group),40 cases for each group,the control group A was taken the rehabilitation intervention,the control group B was treated by the ganglioside,the study group was treated by the ganglioside combined with the active rehabilitation treatment.The Fugl-Meyer(FMA),the National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI) were used to evaluate the efficacy and endpoints before and after treatment.Results After four months,the NIHSS,FMA and ADL scores of three groups were higher than before,and the difference was statistically significant (P ＜ 0.05),and the study group was higher than the control group A and B (P ＜ 0.05).Comparison of clinical efficacy,the cure rate and total effective rate of the study group were significantly higher than those of the control A,B group (P ＜ 0.05).Conclusion Ganglioside combined with early rehabilitation treatment can promote the ACI patients to return to motor function of limbs,improve the level of nerve function defect and improve the ADL; it' s a train of thought to further optimize the cerebral infarction treatment.