Effect of ganglioside combined with vinpocetine therapy on neural functional reconstruction in convalescents with acute cerebral infarction

摘要

Objective:To analyze the effect of ganglioside combined with vinpocetine therapy on neural functional reconstruction in convalescents with acute cerebral infarction.Methods:A total of 92 convalescents with acute cerebral infarction treated between in our hospital between January 2013 and January 2016 were selected and randomly divided into observation group and control group (n=46). Control group received basic treatment, observation group received basic treatment + ganglioside combined with vinpocetine therapy, and then differences in cerebral blood perfusion parameters as well as serum levels of nerve function, hemorrhagic transformation, blood coagulation function and other related indexes were compared between two groups of patients after treatment.Results:Cerebral blood perfusion parameters CBF and CBV values of observation group after treatment were higher than those of control group while MTT and TTP values were lower than those of control group; serum nerve growth-related factors MBP, GAP-43 and TGF-β1 levels of observation group after treatment were lower than those of control group while BDNF, NGF and IGF-1 levels were higher than those of control group; serum hemorrhagic transformation-related indexes MMP-2, MMP-9, GFAP and FN levels of observation group after treatment were lower than those of control group while PAI level was higher than that of control group; serum blood coagulation-anticoagulation system-related factors vWF, TM, PC,β-TG and PF4 levels of observation group after treatment were lower than those of control group.Conclusions:Ganglioside combined with vinpocetine can promote the neural functional reconstruction and inhibit the occurrence of cerebral hemorrhage and cerebral re-infarction in convalescents with acute cerebral infarction.