Objective To explore and analyze the efficacy of azithromycin in the combination with ambroxol hydrochloride in the treatment of mycoplasma pneumoniae pneumonia and its effect on IL-10 and TNF-α.Methods 120 patients with mycoplasma pneumoniae pneumonia treated at our hospital from September,2013 to September,2015 were selected and were randomly divided into an one-drug group and a combination group,60 for each group.The one-drug group were treated with azithromycin and the combination group azithromycin and ambroxol hydrochloride.The clinical curative effect,the times for the disappearance of main symptoms,and the serum levels of IL-10 and TNF-α were compared between these two groups.Results The total effective rate was higher and the times for the disappearance of fever,cough,lung shadow,and lung rale were shorter in the combination group than in the one-drug group,with statistical differences (P＜0.05).The levels of TNF-α and IL-10 were obviously lower after than before the treatment and were in the combination group than in the one-drug group after the treatment,with statistical differences (P＜0.05).Conclusions Azithromycin in the combination with ambroxol hydrochloride in the treatment of mycoplasma pneumoniae pneumonia is effective and can lower the serum levels of TNF-α and IL-10,so it is worth being generalized.%目的 探究与分析阿奇霉素联合盐酸氨溴索治疗肺炎支原体肺炎的效果及对IL-10、TNF-α的影响.方法 选取本院2013年9月至2015年9月收治的120例肺炎支原体肺炎患者,采用随机数字表法分为单独用药组与联合用药组,各60例.单独用药组阿奇霉素治疗,联合用药组加用盐酸氨溴索治疗,对比两组临床疗效、主要症状消失时间及血清IL-10、TNF-α水平.结果 联合用药组总有效率高于单独用药组,差异具有统计学意义(P＜0.05).联合用药组发热持续时间、咳嗽缓解时间、肺部阴影消退时间及肺部啰音消失时间均短于单独用药组,差异具有统计学意义(P＜0.05).两组治疗后TNF-α、IL-10水平均较治疗前明显降低,与单独用药组相比联合用药组TNF-α、IL-10水平降低更显著,差异具有统计学意义(P＜0.05).结论 阿奇霉素联合盐酸氨溴索治疗肺炎支原体肺炎的效果显著,可降低血清因子IL-10、TNF-α水平,值得推广.
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