临床药师干预清洁手术围术期预防性使用抗菌药物的临床效果

摘要

Objective To explore the clinical effect of the intervention by clinical pharmacist of perioperative prophylactic antibiotics in aseptic operation.Methods The clinical data of 100 patients discharged from our hospital from January,2013 to January,2014 (after the intervention) and 100 patients from March,2011 to March,2012 (before the intervention) after aseptic operation were retrospectively analyzed.The clinical effects of perioperative prophylactic antibiotics in aseptic operation were compared and analyzed.The data were recorded on a table and saved and were statistically analyzed with SPSS 15.0.Results Before the intervention,91 patients (91％) perioperatively and prophylacticly took antibiotics;and after the intervention,45 (45％).The proportion of using prophylactic antimicrobial drugs decreased from 9％ before the intervention to 1％ after the intervention.The choices of antimicrobial drugs were more rational,up to 98％.The drug treatment course was more scientific (increased from 38％ to 82％).The medical cost had also been significantly lowered.The cost of prophylactic antibiotics accounted for 1.45％ of total drug cost.The hospital stay was shortened.Conclusions The intervention by clinical pharmacist of perioperative prophylactic antibiotics in aseptic operation is clinically effectibve,can rationalize the use of antibiotics,lower medical cost,and shorten hospital stay,and is safe and feasible and worth being clinically generalized.%目的 探究临床药师干预清洁手术围手术期预防性使用抗菌药物的临床效果.方法 采用回顾性分析方法,将2013年1月至2014年1月(干预后)以及2011年3月至2012年3月(干预前)本院200例清洁手术出院患者的临床资料作为本次研究的对象,每个阶段各100例,对这200例清洁手术患者的围手术期预防性使用抗菌药物的临床疗效进行比较分析,并采用表格形式对这些数据进行录入保存,采用SPSS 15.0统计学软件对这些数据进行统计学分析.结果 在临床药师干预之前,共有91例患者在围手术期预防性使用抗菌药物,占91％,经过临床医师的有效干预,使用预防性抗菌药物的患者下降到45例,占45％,联合使用预防性抗菌药物的比例由原来的9％下降至1％,对抗菌药物的选择更加合理化,达98％,用药的疗程也更加科学,由原有的38％上升到82％.另外,在医疗费用上也有了明显改善,所用预防性抗菌药物费用占药品费用的1.45％,患者住院天数也在一定程度上有所减少.结论 临床药师干预清洁手术围手术期预防性使用抗菌药物具有明显的临床效果,不仅能够使抗菌药物的使用更加合理化,而且能够在一定程度上降低患者的医疗费用,减少患者住院天数,具有一定的安全性与可行性,可以在临床中广泛应用.