甲氨蝶呤、柳氮磺吡啶、硫酸羟氯喹单独与联合用药治疗类风湿性关节炎对血脂的影响

摘要

Objective To investigate the influence of methotrexate, sulfasalazine, and hydroxychloroquine sulfate alone or combination of these 3 drugs in the treatment of rheumatoid arthritis on blood lipids.Methods 120 patients with rheumatoid arthritis treated at our hospital from January, 2013 to December, 2014 were collected for prospective study and were randomly divided into group A, group B, group C, and group D, 30 cases for each group.Group A orally took methotrexate, group B sulfasalazine, group C hydroxychloroquine sulfate, and group D all these 3 drugs.The biochemical and clinical indicators were compared between these four groups before and after the treatment.Results The biochemical tests and clinical parameters were significantly improved after the treatment in all 4 groups, with statistical differences (P＜0.01).After the treatment, there were statistical differences in levels of TC [(4.20±0.65) mmol/L vs.(4.76±0.84) mmol/L, (4.82±0.93) mmoFL, (4.79±0.88) mmol/L], TG[(1.03±0.41) mmol/L vs.(1.41±0.61) mmol/L, (1.42±0.63) mmol/L, (1.43±0.57) mmol/L], LDL [(2.01±0.45) mmol/L vs.(2.45±0.65) mmol/L, (2.44±0.71) mmol/L, (2.47±0.62)mmol/L], HDL[(1.69±0.35) mmol/L vs.(1.25±0.30) mmol/L, (1.27±0.29) mmol/L, (1.32±0.31) mmol/L], and the number of swollen joints [(3.01±0.97) vs.(4.38±1.25), (4.37±1.31), (4.39±1.28)] between group D and group A, group B, and group C (P ＜0.01).Conclusions The combination of methotrexate, sulfasalazine, and hydroxychloroquine sulfate can improve the lipid levels of patients with rheumatoid arthritis and is worth for reference.%目的 探讨甲氨蝶呤、柳氮磺吡啶、硫酸羟氯喹单独与联合用药治疗类风湿性关节炎对血脂的影响.方法 收集我院2013年1月至2014年12月收治的类风湿性关节炎患者120例进行前瞻性研究且随机分为A、B、C、D四组,每组30例.A组口服甲氨蝶呤,B组口服柳氮磺吡啶,C组口服硫酸羟氯喹,D组则联合服药.比较四组治疗前后生化检查与相关临床指标.结果 四组治疗后生化检测与临床指标均显著改善,差异有统计学意义(P＜0.01)D组治疗后TC[(4.20±0.65) mmol/L vs.(4.76±0.84)mmol/L、 (4.82±0.93) mmol/L、 (4.79±0.88) mmol/L]、TG[(1.03±0.41) mmol/Lvs.(1.41±0.61)mmol/L、 (1.42±0.63) mmol/L、 (1.43±0.57) mmol/L]、LDL[(2.01±0.45) mmol/L vs.(2.45±0.65)mmol/L、(2.44±0.71) mmol/L、(2.47±0.62) mmol/L]水平与A组、B组、C组比较,差异有统计学意义(P＜0.01);D组治疗后HDL水平[(1.69±0.35) mmol/L vs.(1.25±0.30) mmol/L、(1.27±0.29) mmol/L、(1.32±0.31) mmol/L]与关节肿胀个数[(3.01±0.97) vs.(4.38±1.25)、(4.37±1.31)、(4.39±1.28)]与A组、B组、C组比较,差异有统计学意义(P＜0.01).结论 甲氨蝶呤、柳氮磺吡啶、硫酸羟氯喹联合用药可显著改善类风湿性关节炎患者血脂水平,具有借鉴性.