肝癌患者癌组织及血清中CD163的表达水平及意义

摘要

目的 探究CD163在原发性肝癌患者癌组织及血清中的表达水平及其临床意义.方法 选取2013年9月至2016年9月于本院诊治的100例原发性肝癌患者为观察组研究对象,同期本院体检正常者50例为对照组研究对象,比较两组研究对象癌组织(正常肝组织)及血清中CD163的表达水平.结果 观察组CD163在癌组织中的表达水平显著高于对照组CD163在正常肝组织中的表达水平[(47.96±13.35) ng/ml比(20.50±6.57) ng/ml],差异具有统计学意义(t=13.721 0,P=0.000 0);观察组CD163在血清中的表达水平显著高于对照组[(2000.25±833.11) ng/ml比(307.76±140.18) ng/ml],差异具有统计学意义(t=14.241 5,P=0.000 0).结论 原发性肝癌患者癌组织及血清中CD163表达水平均显著升高,可为临床诊断肝癌提供重要参考.%Objective To study the clinical significance and expression levels of CD163 in cancer tissues and serum of patients with liver cancer.Methods From Sep.2013 to Sep.2016,a total of 100 patients with primary liver cancer treated at our hospital were taken as clinical objects,and they were set as an observation group.At the same time,50 healthy persons were selected as a control group.The expression levels of CD163 in cancer tissues,normal liver tissues and serum were compared.Results The expression level of CD163 in the cancer tissue in the observation group was (47.96±13.35) ng/ml,which was obviously higher than that in the normal liver tissue in the control group [(20.50±6.57) ng/ml],with a statistical difference (t=13.721 0,P=0.000 0).The expression level of CD 163 in the serum in the observation group was (2 000.25±833.11) ng/ml,which was obviously higher than that in the serum in the control group [(307.76±140.18) ng/ml],with a statistical difference (t=14.241 5,P=0.000 0).Conclusion The expression levels of CD163 in the cancer tissue and serum of patients with primary liver cancer are significantly increased,which can provide important reference for the clinical diagnosis of liver cancer.