目的 分析多囊卵巢综合征患者血清抗苗勒管激素与胰岛素抵抗水平的相关性.方法 选取本院2016年1月至11月81例多囊卵巢综合征患者为观察组,另选40例输卵管性不孕患者为对照组,各观察指标比较.结果 观察组血清抗苗勒管激素[(12.64±5.74) ng/ml]、黄体生成素[(12.34±7.09)mlU/ml]、黄体生成素/促卵泡激素[(3.16±1.45)]、睾酮[(0.51±0.17) ng/ml]、空腹胰岛素[(10.13±3.98)mIU/ml]、胰岛素抵抗指数[(2.17±0.87)]、体质量指数[(24.13±3.40) kg/m2],对照组血清抗苗勒管激素[(5.44±3.03) ng/ml]、黄体生成素[(4.24±2.63) mIU/ml]、黄体生成素/促卵泡激素[(1.09±0.53)]、睾酮[(0.40±0.12)ng/ml]、空腹胰岛素[(7.27±1.68) mIU/ml]、胰岛素抵抗指数[(1.46±0.39)]、体质量指数[(20.90±3.65) kg/m2],差异有统计学意义(P＜0.05).Spearman相关分析提示,多囊卵巢综合征患者血清抗苗勒管激素与胰岛素抵抗水平呈正相关(r=0.502,P=0.000),直线回归分析显示两者间有直线关系(R2=0.256).结论 多囊卵巢综合征患者血清抗苗勒管激素与胰岛素抵抗水平呈正相关,可作为早期诊断指标及临床治疗新思路.%Objective To analyze the correlation between serum anti-Müllerian hormone and insulin resistance in patients with polycystic ovary syndrome (PCOS).Methods Eighty-one patients with polycystic ovary syndrome in our hospital from January to November in 2016 were selected as the observation group,40 patients with tubal infertility were selected as the control group.Compared the clinical indexes.Results There were statistically significant differences in serum anti-Müllerian hormone,luteinizing hormone,luteinizing hormone / follicle stimulating hormone,testosterone,fasting insulin,insulin resistance index,body mass index between the observation group and the control group [(12.64±5.74)ng/ml vs.(5.44±3.03)ng/ml,(12.34±7.09) mIU/ml vs.(4.24±2.63)mIU/ml,(3.16±1.45) vs.(1.09±0.53),(0.5 1±0.17)ng/ml vs.(0.40±O.12)ng/ml,(10.13±3.98) mIU/ml vs.(7.27±1.68)mIU/ml,(2.17±0.87) vs.(1.46±0.39),(24.13±3.40)kg/m2 vs.(20.90±3.65)kg/m2].Spearman correlation analysis suggested that serum anti-Müllerian hormone was positively correlated with insulin resistance level in patients with polycystic ovary syndrome (r=0.502,P=0.000);and linear regression analysis showed that there was a linear relationship between the two indexes (R2=0.256).Conclusion Serum anti-Müllerian hormone is positively correlated with insulin resistance in patients with polycystic ovary syndrome,which can be used as an early diagnosis index and new clinical treatment.
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