丹红注射液联合依达拉奉对急性缺血性脑卒中患者血管内皮功能、血液流变学影响及疗效观察

摘要

Objective To investigate the clinical efficacy of Danhong injection combined with edaravone in the treatment of patients with acute ischemic stroke and its effect on vascular endothelial function and hemorheology.Methods 80 cases of acute ischemic stroke were randomly divided into research group (n=40) and control group (n=40).Control group was treated with edaravone,and research group was treated with Danhong injection on the basis of the treatment in control group.Both groups were treated for 2 weeks.Made a comparison of the clinical efficacy after 2 weeks,the changes of nervous functional defects score,vascular endothelial function,and hemorheology levels before and 2 weeks after treatment,and the incidence of adverse reactions during 2 weeks of treatment course in both groups.Results There was statistically significant difference in the total effective rate of treatment after 2 weeks between two groups (P＜0.05).After 2 weeks' treatment,nervous functional defects score in research group was significantly lower than that in control group,the levels of VE-cadherin and vWF in research group were significantly lower than those in control group,high shear viscosity,plasmic viscosity,and low shear viscosity in research group were significantly lower than those in control group,with statistically significant differences (P＜0.05).There were no serious adverse reactions during 2 weeks of treatment course.Conclusion Danhong injection combined with edaravone in the treatment of patients with acute ischemic stroke has striking clinical effect,which can improve the vascular endothelial function and hemorheology,with fine safety.%目的 探讨丹红注射液联合依达拉奉对急性缺血性脑卒中患者血管内皮功能、血液流变学影响及疗效.方法 急性缺血性脑卒中患者80例随机分为研究组与对照组,每组40例.对照组采用依达拉奉治疗,研究组在依达拉奉基础上结合丹红注射液治疗.两组患者治疗疗程均为2周.对比两组患者治疗2周疗效,治疗前与治疗2周后神经功能缺损程度评分、血管内皮功能及血液流变学水平变化,用药2周期间不良反应情况.结果 两组患者治疗2周总有效率对比差异有统计学意义(P＜0.05);研究组治疗2周后神经功能缺损程度评分低于对照组,差异有统计学意义(P＜ 0.05);研究组治疗2周后VE-cadherin和vWF低于对照组,差异有统计学意义(P＜0.05);研究组治疗2周后全血黏度高切、血浆黏度、全血黏度低切低于对照组,差异有统计学意义(P＜0.05);两组患者在用药2周期间均未见严重药物不良反应.结论 急性缺血性脑卒中患者应用丹红注射液联合依达拉奉疗效明显,可改善患者血管内皮功能和血液流变学,且用药安全性良好.