Objective To study the expression of Slit2 protein in serum of patients with severe hepatitis B and to analyze its correlation with liver biochemical indexes. Methods 92 cases of severe hepatitis B treated in our hospital from January 2015 to December 2016 were selected as the observation group; during the same period, 92 normal residents were selected as the control group. The patients in the observation group were divided into the recovery group and the non recovery group according to the recovery of the disease. Observed the expression of Silt2 in serum of different groups and analyzed the correlation between the expression of Silt2 and the biochemical indexes of liver function. Results The levels of Slit2 protein, TBIL, and ALT in the observation group were significantly higher than those in the control group (P<0.05), the level of PTA was lower than that in the control group (P<0.05). The patients in the observation group were followed up for 1 month and 50 patients were followed up. Among them, 27 patients recovered and 23 patients did not recover. The Slit2 protein and PTA levels in the recovery group were significantly higher than those in the non recovery group (P<0.05); the levels of TBIL and ALT were significantly lower than those in the non recovery group (P<0.05). There was a positive correlation between the expression of Slit2 and PTA (r=0.367, P<0.05); there was a negative correlation between the expression of Slit2 and TBIL, ALT (r=-0.36, -0.318; P<0.05). Conclusion Serum Slit2 protein level can reflect the prognosis of patients with severe hepatitis B, provides effective reference for clinical treatment, is a kind of important indicator in the evaluation of the prognosis of patients with severe hepatitis B.%目的 研究Slit2蛋白在乙型重型肝炎患者血清中的表达水平,同时分析其与肝功能生化指标的相关性.方法 选取本院在2015年1月至2016年12月期间收治的92例乙型重型肝炎患者作为观察组,同时选取92例正常居民作为对照组.观察组患者根据病情恢复情况分成恢复组与未恢复组.观察不同组对象血清中Silt2表达情况,并分析其与肝功能生化指标的相关性.结果 观察组患者Slit2蛋白、TBIL、ALT水平显著高于对照组(P<0.05),而PTA水平低于对照组(P<0.05);观察组患者治疗后随访1个月,能随访的患者有50例,其中27例患者恢复,23例患者未恢复,恢复组患者Slit2蛋白、PTA水平显著高于未恢复组(P<0.05),而TBIL、ALT显著低于对照组(P<0.05);经Pearson分析,Slit2蛋白与PTA呈正相关(r=0.367,P<0.05),与TBIL、ALT呈负相关(r=-0.461,r=-0.318,P<0.05).结论 血清Slit2蛋白水平可反映乙型重型肝炎患者的预后情况,为临床治疗提高有效的参考依据,是帮助诊断乙型重型肝炎预后的重要指标.
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