厄贝沙坦联合非洛地平缓释片治疗高血压合并糖尿病的疗效及其对血清TGF-β、尿白蛋白的影响

摘要

目的 探讨非洛地平缓释片与厄贝沙坦联合治疗高血压合并糖尿病的疗效及其对血清转化生长因子-β(TGF-β)、尿白蛋白(mAlb)的影响.方法 将103例高血压合并糖尿病患者按治疗方法分为观察组52例,对照组51例.对照组予以非洛地平缓释片治疗,观察组于对照组基础上联合厄贝沙坦治疗.分析比较两组临床效果、肾功能指标[mAlb、肌酐(Scr)、内生肌酐清除率(Ccr)、尿素氮(BUN)]水平、血清TGF-β 水平、及生活质量(SF-36)评分.结果 观察组临床效果显著优于对照组(Z=4.011,P=0.000);治疗2个月后两组Ccr、Scr、BUN、mAlb水平及血清TGF-β 水平均优于治疗前,且观察组显著优于对照组,差异有统计学意义(P<0.05);治疗2个月后两组生理职能、躯体功能、生命活力、心理健康等SF-36评分均高于治疗前,且观察组SF-36评分显著高于对照组,差异有统计学意义(P<0.05).结论 非洛地平缓释片与厄贝沙坦联合治疗高血压合并糖尿病患者效果显著,可明显改善其肾功能及血清TGF-β 水平,且有助于提升其生活质量,具有重要应用价值.%Objective To investigate the curative effect of irbesartan combined with felodipine sustained-release tablets in the treatment of hypertension complicating by diabetes mellitus and its effect on serum transforming growth factor-β (TGF-β) and urinary albumin (mAlb). Methods 103 patients with hypertension complicating by diabetes mellitus were divided into control group (n=51) and observation group (n=52) according to the therapeutic methods. The control group was treated with felodipine sustained release tablets, and the observation group was treated with irbesartan on the basis of the control group. Clinical effect, the levels of renal function indicators [mAlb, creatinine (Scr), endogenous creatinine clearance (Ccr), urea nitrogen (BUN)], serum TGF-β level, and quality of life (SF-36) score of both groups were analyzed and compared. Results The clinical effect of the observation group was significantly better than that of the control group (Z=4.011, P=0.000). After 2 months of treatment, the levels of Ccr, Scr, BUN, mAlb, and serum TGF-βlevel were better than those before treatment in both groups, and those in the observation group were significantly better than those in the control group (P<0.05). After 2 months of treatment, the SF-36 scores of the two groups were higher than those before treatment, and the SF-36 scores of the observation group were significantly higher than those of the control group (P<0.05). Conclusion Felodipine sustained release tablets combined with irbesartan has significant effect in the treatment of hypertension complicating by diabetes mellitus, which can significantly improve the renal function and serum TGF-β level, helps to improve their quality of life, with important application value.