破骨细胞促进骨重建的研究进展

摘要

Bone remodeling is of important value in dental research, and osteoclasts play a positive and non-substitutive role in bone remodeling. However, there are limited researches and clinical therapeutic strategy for bone diseases aiming at the coupling between osteoclasts and osteoblasts, in other words, making use of the positive effect of osteoclasts to promote bone remodeling. This review focused on research progress on the dynamic coupling between bone resorption and bone formation, the positive effect of osteoclasts to promote bone remodeling and its underlying molecular mechanism.%骨重建在口腔医学领域具有重要的价值，而破骨细胞对于骨重建具有不可替代的促进作用。目前，以破骨细胞-成骨细胞耦联为靶向，即利用破骨细胞促进骨重建的研究和应用极少。本文就骨吸收和骨生成间的动态耦联、破骨细胞对骨重建的促进作用、破骨细胞促进骨重建的分子机制等研究进展作一综述。