Objective Try to develop a symptom-based questionnaire for identifying COPD in China .Methods 720 participants were randomly divided into "development subsample" ( 570 cases) and"external validation subsample" ( 150 cases) ,all fulfilled the questionnaires and the pulmonary function test .The "development subsample" was used to create the questionnaires ,while a "external validation subsample"was used to evaluate the performance characteristics of the questionnaires . Results There were 16 items for analysis ,which was reduced to 8 items had significant relationships with the study diagnosis of COPD ,including age ,BMI ,total smoking (annual packs) ,cough and phlegm without a cold , weather-affected cough ,morning phlegm ,wheeze frequency and history of any allergies .Scores for individual questions were based on the regression coefficients from logistic regression models .We created a cut-off value of 17 .5 points by ROC analysis , the sensitivity and specificity were 80％ and 70％ . Conclusions The questionnaires can help preliminary screen COPD patients in China .%目的 对建立适用于中国患者的基于症状的慢性阻塞性肺疾病(COPD)筛查问卷进行初步探讨.方法 720例入选患者被随机分为推导组(570例)和外部验证组(150例),均填写筛查问卷并进行肺通气功能检查.推导组资料经统计学分析确定问卷条目分值,验证组资料用以验证问卷的有效性.结果 16个问卷条目中有8项条目进入最终问卷,分别是年龄、体质量指数(B M I)、吸烟总量(年包)、不感冒时咳嗽咳痰、天气变化时咳嗽、晨起咳痰、气促指数、过敏史.经多元回归分析得出问题条目评分值,ROC曲线分析结果表明以17.5分为截断点时,问卷的敏感性为80％,特异性为70％.结论 初步研究形成的基于症状的COPD筛查问卷可用来筛查中国的COPD高危人群.
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