儿童侵袭性真菌病诊断进展

摘要

Invasive fungal disease (IFD) is common in immunocompromised children,particularly in those with hematological malignancies.IFD is associated with onset complications and can cause high morbidity and mortality.In recent years,the incidence of IFD is increasing.More cases are reported in non-neutropenic and immunocompetent children without apparent underlying conditions.Early diagnosis and prompt therapy is key to better prognosis.This review focuses on the diagnostic methods on IFD.%侵袭性真菌病(invasive fungal disease,IFD)常发生在免疫功能低下的儿童,尤其是血液系统恶性疾病儿童,合并早晚期并发症,有较高的病死率,严重威胁着患儿的健康.近年来,IFD发病率呈上升趋势,非白色假丝酵母菌和曲霉菌所致感染增加,也有越来越多关于非中性粒细胞减少、无基础疾病免疫功能正常儿童侵袭性真菌病的报道.早期准确诊断,并给予针对性的抗真菌治疗是儿童IFD管理的关键.该文对IFD诊断方法进行综述.