In vitro diagnostic method of an invasive mycosis by MALDI-TOF mass spectrometry

摘要

In vitro diagnostic method of an invasive mycosis caused by a pathogenic fungal microorganism, characterized by: - providing a sample of a biological liquid that comes from a mammal, wherein said biological liquid contains especially proteins and / or lipids and / or salts and / or polysaccharides and / or oligosaccharides and / or monosaccharides capable of complexing with said proteins and / or lipids and / or salts; - treating said biological liquid sample to extract said polysaccharides and / or oligosaccharides and / or monosaccharides; - determine by mass spectrometry of the MALDI-TOF type the presence or not, among said polysaccharides, oligosaccharides and / or monosaccharides extracted, of at least one compound of interest given that it comes from said fungal microorganism and chosen among the polysaccharides, oligosaccharides and the monosaccharides; - deduce that if said compound of interest given is present in said sample, said mammal is affected by an invasive mycosis.