允许性高碳酸血症在急性肺损伤治疗中的研究

摘要

Mechanical ventilation can increase the survival rate of acute lung injury significantly,but the traditional ventilation can cause ventilator-induced lung injury.Permissive hypercapnia can alleviate barotrauma and volutrauma which are caused by the traditional mechanical ventilation,reduce proinflammatory or inflammatory cytokines release,decrease cell apoptosis,improve pulmonary ventilation function,regulate vascular contraction and relaxation and so on.It has a prospect in the treatment of acute lung injury.But it can suppress the immune response and alveolar epithelial repair,reduce pulmonary edema fluid absorption and other adverse effects.Those adverse effects limit clinical application of permissive hypercapnia.%机械通气可提高急性肺损伤患儿的存活率,但传统通气模式可致机械通气相关性肺损伤.允许性高碳酸血症能够减少传统机械通气中引起的气压伤及容积伤、减少(前)炎症因子释放、减少细胞凋亡、改善通气以及参与血管调节等作用；但也有抑制免疫反应、影响肺泡上皮修复以及减少肺水肿液的吸收等不良作用,限制了其在临床的应用.