流感相关的宿主遗传易患性研究进展

摘要

遗传易患性是指由于遗传因素的影响,使机体具有容易发生某种疾病的特性.随着对感染性疾病遗传易患性的进一步认识和人类基因组研究的深入,世界卫生组织提出了优先对流感的遗传易患性进行研究.流感患者的相关家系研究提示遗传易患性是导致季节性和流行性流感患者死亡的危险因素之一.流感相关的动物实验和临床研究表明影响病毒复制的宿主遗传因素可能是决定流感病情和预后的主要因素.基因测序技术的迅猛发展为进一步阐明宿主遗传因素在流感发病机制中的作用提供了契机,由于人类基因在不同的人种和地域之间存在着差异,在不同的国家、研究机构中共同开展同质化的科研协作将有助于进一步揭示流感的发病机制.%Genetic susceptibility is the characteristic that the organism is vulnerable to a disease caused by hereditary factors.As the knowledge to genetic susceptibility of infectious diseases and human genome research develops,the WHO has suggested it should be prior to study the genetic susceptibility of influenza.The related familial study of influenza patients proposed genetic susceptibility is one of the death risk factors of seasonal and pandemic influenza patients.The animal and clinical studies which were associated with influenza indicated the host genetic factor that affected viral replication might be the major factor to determine the influenza condition and prognosis.The rapid development of genome sequencing technology has provided an opportunity to further clarify the role of host genetic factor in pathogenesis of influenza.As the human genome is diverse ethnically and geographically,to carry out the homogeneous research collaboration will help to reveal the pathogenesis of influenza.