炎症介质在坏死性小肠结肠炎发病机制中的作用

摘要

Necrotizing enterocolitis ( NEC) is a common neonatal emergency and severe case. It is a se-rious threat to the neonates. Apoptotic signal transduction pathway can be classified into extrinsic apoptotic path-way,the intrinsic apoptosis pathway and endoplasmic reticulum pathways. Inflammatory mediators can induce apoptosis in intestinal epithelial cells through the three ways mentioned above. It plays an important role in the development of NEC,which might be important for the pathogenesis of NEC.%坏死性小肠结肠炎( necrotizing enterocolitis,NEC)是新生儿常见的危急重症,严重威胁新生儿的健康。凋亡信号传导途径可以分为外源性凋亡途径、内源性凋亡途径和内质网途径。新生儿发生NEC时炎症介质可通过以上三种途径诱导肠上皮细胞凋亡,在NEC的发生发展过程中起着重要的作用,是导致NEC发病的重要机制。