新生儿中性粒细胞呼吸爆发功能的研究进展

摘要

Neutrophil respiratory burst is like a double-edged sword.On one hand, newborns rely mainly on neutrophil against infection.On the other hand, newborns are succeptible to be damaged by reactive oxygen species.Studies have already suggested that reactive oxygen species have relationship with neonatal diseases, such as sepsis,bronchopulmonary dysplasia,but it still remains controversial.This paper provides an overview of the measurement of neutrophil respiratory burst, and the relationship of neutrophil respiratory burst with neonatal sepsis,as well as with bronchopulmonary dysplasia.%中性粒细胞呼吸爆发是把"双刃剑",一方面,中性粒细胞呼吸爆发在新生儿抵抗感染中扮演着重要的角色;另一方面,新生儿体内抗氧化物不足,容易受到中性粒细胞呼吸爆发所产生的活性氧物质损伤.已经有研究显示中性粒细胞呼吸爆发和新生儿新生儿疾病密切相关,如新生儿感染及支气管肺发育不良,但仍存在争议.该文从中性粒细胞呼吸爆发的炎症效应及检测方法、中性粒细胞呼吸爆发与新生儿感染以及中性粒细胞呼吸爆发与支气管肺发育不良三个部分对新生儿中性粒细胞呼吸爆发功能的研究进展进行综述.