轮状病毒感染的肠道外损伤发病机制研究进展

摘要

轮状病毒是引起婴幼儿秋冬季腹泻最常见的病原体之一.轮状病毒感染不仅可引起严重的胃肠道症状,胃肠道外的感染及器官损伤得到越来越多的重视.循环系统、神经系统、呼吸系统等人体多个系统均可能出现损害.了解轮状病毒感染造成多系统损害的发生机制对治疗轮状病毒感染性腹泻有重要的临床指导意义,同时提示在治疗轮状病毒感染性腹泻上,不仅要纠正严重的脱水、酸中毒及离子紊乱,更需要注意各脏器功能的保护.%Rotavirus is the most common cause of infantile diarrhea in autumn and winter.Rotavirus not only induces severe gastrointestinal symptom,but also arise multisystem complication,such as circulatory system,nervous system,respiratory system.Mastering multisystem damage mechanism of rotavirus has important significance to our future treatment.Not only we should correct severe dehydration,acidosis and electrolyte disorder,but protect important organ functions.