脂肪组织线粒体自噬研究进展

摘要

Mitophagy is a process that selectively break down the damaged or unwanted mitochondria through autophagy and is a regulatory mechanism for maintaining intracellular mitochondrial quantity and mass balance.Adipose tissue is an important endocrine tissue that maintains energy balance and is generally divided into three types:white adipose tissue,brown adipose tissue and beige adipose tissue.There are specific biological processes in adipocyte differentiation stage that are specifically regulated by autophagy regulators.Mitophagy plays a central role in the function and maintenance of metabolic tissues such as liver,pancreas,and adipose tissues.The specific enhancement or inhibition of mitophagy,may be another new therapeutic direction of obesity,diabetes and other metabolic diseases.This paper reviews the progress between mitophagy and obesity,and its mechanism and regulation.%线粒体自噬是通过自噬机制选择性清除受损伤或不必需的线粒体的过程,是保持细胞内线粒体数量和质量平衡的一种调控机制.脂肪是维持体内能量平衡的重要的内分泌组织,普遍被分为3种类型:白色脂肪组织、棕色脂肪组织和米色脂肪组织.线粒体自噬在不同种类、不同分化阶段的脂肪组织中具有不同的功能状态,通过研究其在肥胖发生发展中的作用,特异性增强或抑制细胞内的线粒体自噬,可能为肥胖、糖尿病等代谢性疾病提供新的治疗思路和方向.该文就线粒体自噬的机制、调控及其与肥胖的研究进展进行综述.