根治手术与姑息手术治疗TNMⅢ期胰腺癌患者效果及存活质量、时间比较

摘要

Objective:To compare the effects, survival quality and time between radical operation and palliative operation in treating patients with TNMⅢstage pancreatic cancer. Methods:Sixty patients withⅢstage pancreatic cancer who were treated in our hospital between January 2011 and December 2014 were divided into radical operation group (group A, n=34) and palliative operation group (group B, n=26). hTe incidence of postoperative complications, survival quality and postoperative 1-, 2-and 3-year survival rates were compared between two groups. Results:There were no significant differences in ClavienⅢ, ClavienⅣand incidence of pancreatic ifstula between two groups atfer operation (P>0.05);the incidence rate of ClavienⅡin group A (41.2%) was signiifcantly higher than group B (15.4%) (P<0.05). Quality of life scores in group A were higher than group B (P<0.05). hTe 1-, 2-and 3-year survival rates in group A were 44.2%, 21.2%and 16.1%respectively, while in group B were 15.4%, 8.0% and 0, respectively (P>0.05). Conclusion: The effect of radical operation in the treatment of patients with TNM Ⅲ stage pancreatic cancer is better, and the postoperative 1-, 2- and 3-year survival rates are higher than palliative operation. The quality of life is higher and it will not increase postoperative complications.%目的：比较根治手术与姑息手术治疗TNMⅢ期胰腺癌患者效果、存活质量及存活时间。方法：选择我院2011年1月至2014年12月收治的60例Ⅲ期胰腺癌患者进行回顾性分析，根据患者手术方式分为根治性手术组(A组，n=34)及姑息手术组(B组，n=26)，比较两组术后并发症发生率、存活质量及术后1年、2年、3年生存率。结果：两组术后ClavienⅢ级、ClavienⅣ级及胰瘘发生率无统计学差异(P>0.05)；A组ClavienⅡ级发生率为41.2%，高于B组15.4%(P<0.05)；A组各项生活质量评分均高于B组(P<0.05)；术后1、2、3年生存率分别为44.2%、21.2%、16.1%，B组为15.4%、8.0%、0，无统计学差异(P>0.05)。结论：根治手术治疗TNMⅢ期胰腺癌患者可取得更佳效果，术后1、2、3年生存率均高于姑息手术组，生活质量更高，且术后并发症未明显增加，具有较大可行性。