骨扫描与肿瘤标志物联检在骨转移诊断中的应用进展

摘要

Bone is one of the most common metastatic sites for advanced cancers.The skeletal-related events caused by bone metastases could have a significant influence on patient's clinical outcome and quality of life.Currently,bone scintigraphy is the first choice for detecting bone metastases.Although the sensitivity is high,the specificity of bone scintigraphy is still very low.It has been reported that by combining bone scintigraphy and tumor markers,the specificity can be significantly increased.Meantime,the sensitivity and accuracy of bone scintigraphy in diagnosis of bone metastases can be improved.We reviewed the literatures in the recent years to evaluate the potential value of combination with bone scintigraphy and tumor markers in the diagnoses of bone metastases.%骨骼是晚期恶性肿瘤最常见的扩散转移部位之一.由骨转移引发的骨相关事件可以明显影响晚期肿瘤病人的生活质量和临床转归.骨扫描目前仍然是诊断骨转移的首选检查方法.尽管骨扫描具有高度的敏感性,但其特异性仍较低,如与不同癌症的相关肿瘤标志物联检,可明显提高骨扫描的诊断特异性,还可不同程度地提高其诊断的敏感性和准确性.就骨扫描与肿瘤标志物联检在骨转移诊断中的应用及其潜在的临床价值予以综述.