高级别胶质瘤治疗后的DWI新技术评估进展

摘要

The current standard treatment for high-grade glioma (HGG) is resection and followed by radiotherapy and concurrent chemotherapy. Tumor recurrence and post-treatment radiation effects (PTRE) are the most important factors influencing overall survival. The PTRE includes pseudoprogression and radiation necrosis. Post-treatment monitoring should identify tumor progression and PTRE early and effectively. At present, DWI is the most common functional technology in assessment of posttreatment HGG. In recent years, some new MR functional technologies provide new approaches for evaluation HGG response to treatment, including mean apparent diffusion coefficient (ADC), minimum apparent diffusion coefficient (ADCmin), apparent diffusion coefficient histogram, and functional diffusion map (fDM).%高级别胶质瘤（HGG）术后治疗主要采用放疗或联合放化疗，肿瘤复发与治疗反应是影响其术后生存最重要的因素，治疗反应包括假性进展和治疗后坏死。治疗后监测需要及早、有效地鉴别真性进展与治疗反应。DWI是目前最常用于HGG治疗后评估的功能MRI技术。近年来开发的平均及最小ADC值、ADC直方图和功能扩散图等DWI新技术对HGG治疗后评估具有独特作用。