恶性肿瘤患者血清Kappa与Lambda轻链检测及临床意义

摘要

Objective To investigate the abnormal expressions of immunoglobulin light chains kappa(Igκ)and Lambda(Igλ)in malignant tumors.Methods The concentrations of the Igκ and Igλ in serum were measured by rat nephelometry in 60 cases of malignant tumors and 15 cases of healthy people.Results The liver tumor patients had a higher concentration of Igκ and Igλ in serum than normal people(P＜0.01).There wre not significant differences between the levels of Igκ,Igλ and κ/λ ratio in the stomach tumor,lung tumor,proctologic/colonic tumor,mammary tumor,oesophagus tumor and normal peoples(P＞0.05).Conclusion The measurment of Igκ,Igλ and κ/λ ratio in serum would be helpful for the diagnosis of the liver tumor.By continous observation with Igκ,Igλ and κ/λratio in serum could predict the development of disease.%目的 探讨恶性肿瘤患者血清中Kappa和Lambda轻链的表达情况.方法 采用免疫散射比浊法对60例恶性肿瘤患者和15例健康体检者血清中Kappa和Lambda轻链进行榆测.结果 肝痛组患者血清中κ和λ值均显著高于健康对照组,且差异有统计学意义(P＜0.01);而κ/λ比值与健康对照组比较,差异尤统计学意义(P＞0.05).胃癌、肺癌、直肠/结肠癌、乳腺癌、食道癌组患者血清中κ、λ、κ/λ比值分别与健康对照组比较,差异无统计学意义(P＞0.05).结论 血清中Kappa和Lambda轻链检测,可作为原发性肝癌的试验诊断指标和对患者体液免疫功能的评价与监测.