急性脑梗死患者血清S-100b蛋白和基质金属蛋白酶-2的含量检测及临床意义

摘要

Objective To observe the changes of S-100b protein and matrix metallporotelnases- 2(MMP -2) in serum of patients with acute cerebral infarction(ACI) and to evaluate the effect and clinical significance in ACI. Methods 56 patients with ACI as case group and 30 health examination persons as control group were selected. ELISA was used to measure the serum levels of S 100b protein and MMP- 2. Comparison analysis was performed by using SPSS17.0 statistical software. Results The serum levels of S-100b protein and MMP- 2 in case group were significantly higher than the control group(P＜0.05) ,S-100b protein level increased to the top on the third day and MMP- 2 level on the seventh day. There was a positive correlation between serum levels of S 100b protein and MMP-2 with the infarction volume and the extent of lesion (P＜0.05). Conclusion The serum levels of S-100b protein and MMP-2 remarkably increased in patients with ACI,and the increasing degree may not only sensitively reflect the infarction volume and the extent of lesion of central nervous system, but also could be main parameter for clinical diagnosis, evaluation and treatment.%目的 观察急性脑梗死(ACI)患者血清S-100b蛋白和基质金属蛋白酶-2(MMP-2)含量的变化,探讨其在ACI发病中的作用及临床意义.方法 选取56例ACI病例为患者组,30例健康体检者为对照组.采用ELISA法动态监测血清S-100b蛋白和MMP-2的浓度,并用SPSS17.0统计软件进行统计学分析.结果 患者组血清S-100b蛋白和MMP-2水平均明显高于对照组,差异有统计学意义(P<0.05),S-100b蛋白浓度于发病后第3天达高峰,MMP-2浓度于发病后第7天达高峰,之后浓度逐渐降低.S-100b蛋白和MMP-2与脑梗死体积大小和损伤程度存在相关性(P<0.05).结论 ACI患者脑血清S-100b蛋白和MMP-2浓度能敏感地反映患者梗死体积和神经功能损伤程度,是ACI临床诊断、病情监测和疗效观察的重要参数.