非酒精肝硬化肝性脑病患者血清FT3、FT4、TSH的化学发光分析

摘要

Objective To detect of non-alcoholic cirrhosis hepatic encephalopathy patients serum thyroxine level changes of serum thyroxine in nonalcoholic cirrhosis hepatic encephalopathy. Methods For screening nonalcoholic cirrhosis hepatic encephalopathy 60 cases regarded as experimental group and 40 normal subjects as control group,extraction of all participants in the fasting venous blood,using a chemiluminescence assay for the detection of serum thyroxine levels. Results The nonalcoholic liver cirrhosis hepatic encephalopathy in patients with FT3,FT4 and TSH three content were lower than the control group,P<0. 01. B group in FT3,FT4 and TSH three content was significantly higher in C group of patients, there is obvious difference between two groups, P<0. 05,with statistical significance. Thyroxine content with cirrhosis level elevation gradually reduced. Non alcoholic cirrhosis hepatic encephalopathy in patients with Child-Pugh grade is higher, the mortality rate is higher,the worse prognosis. Conclusion The serum thyroxine level changes not only in judging the non-alcoholic cirrhosis hepatic encephalopathy severity and prognosis of great value,but also contribute to the identification,assessment of patients at high risk,so as to improve the efficacy of treatment,improve the prognosis of the patients,improve the survival rate.%目的 通过检测非酒精肝硬化肝性脑病患者游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、血清促甲状腺素(TSH)的水平变化,探讨血清甲状腺素在非酒精肝硬化肝性脑病中的临床意义.方法 筛选非酒精肝硬化肝性脑病患者60例(实验组)和健康体检者40例(对照组),抽取所有参与者的空腹静脉血,采用化学发光法检测血清FT3、FT4、TSH的水平.结果 实验组非酒精性肝硬化肝性脑病患者FT3、FT4和TSH 3者的含量均低于对照组(P＜0.01).B级组在FT3、FT4和TSH 3者的含量明显高于C级组患者(P＜0.05).甲状腺素含量随着肝硬化级别的升高逐渐减少.非酒精性肝硬化肝性脑病患者Child-Pugh分级越高,其死亡率越高,预后越差.结论 血清FT3、FT4、TSH水平的变化与肝硬化Child-Pugh分级存在密切相关,检测这些指标对判断病情、估计预后有重要的参考价值.