应用ROC曲线分析确定ELISA法检测泡型包虫病的诊断界值

摘要

目的：应用ROC曲线确定ELISA法检测泡型包虫病的诊断界值。方法筛选经金标准确认的34例泡型包虫病标本，通过ELISA法检测，通过ROC曲线分析确定诊断界值，并根据其诊断界值计算诊断敏感度和特异度。结果当诊断界值为0．44时，ROC曲线下面积最大，为0．995，诊断敏感度为97．06％，特异度为97．06％。结论ROC曲线法是寻找ELISA法诊断界值的最佳方法。%Objective To determine the ELISA cut‐off value for the diagnosis of alveolar echinococcosis by applying ROC curve . Methods 34 cases of alveolar echinococcosis specimens confirmed by the gold standard were selected and detected by ELISA .The diagnostic cut‐off value was determined by ROC curve ,and the sensitivity and specificity were calculated according to the cut‐off value .Results When the cut‐off value was 0 .44 ,the ROC curve had the largest area under the curve (AUC) accounting of 0 .995 , and the sensitivity and specificity w ere 97 .06% and 97 .06% respectively .Conclusion T he ROC curve is the best w ay to determine the cut‐off value of ELISA .