不同妇科疾病患者血清CA125和SCC-Ag水平分析

摘要

目的：检测不同妇科疾病患者血清中糖类抗原125（CA125）和鳞状细胞癌相关抗原（SCC-Ag）的水平，探讨血清CA125和 SCC-Ag在妇科疾病诊断中的临床意义。方法采用化学发光法测定272例妇科住院患者血清CA125和SCC-Ag水平，以门诊体检健康妇女20例作为健康对照组。结果血清CA125在不同妇科疾病中的水平及阳性率均有不同程度的提高，其中以子宫内膜异位症组、子宫腺肌症组、宫颈癌组尤为明显，与健康对照组相比差异均有统计学意义（P＜0．01）。血清SCC-Ag在宫颈癌组中的水平及阳性率较高，与健康对照组相比差异有统计学意义（P＜0．01）。结论血清CA125可作为妇科疾病筛查的一项指标。血清SCC-Ag是宫颈癌较特异的血清肿瘤标志物。%Objective To detect the serum levels of carbohydrate antigen 125(CA125)and squamous cell carcinoma antigen (SCC-Ag)in patients with different gynecological diseases ,and to investigate the clinical significance of serum CA125 and SCC-Ag in the diagnosis of gynecological diseases .Methods The levels of CA125 and SCC-Ag in serum were detected by chemiluminescence method in 272 hospitalized patients of gynecological and 20 health examination women(normal control group) .Results The serum level and the positive rate of CA125 were increased in different disease groups ,which were significantly increased in endometriosis , adenomyosis ,and cervical cancer groups and were significantly different from the normal control group(P<0 .01) .The serum level and positive rate of SCC-Ag in cervical cancer group were significantly higher than normal control group(P<0 .01) .Conclusion Serum CA125 can be used as an indicator of gynecological disease screening ,and serum SCC-Ag is a specific tumor marker of cervi-cal cancer .