海口地区18～60岁健康人群血清甲状腺激素参考区间的调查

摘要

Objective To establish the reference intervals for thyroid-stimulating hormone(TSH) ,triiodothyronine(T3 ) ,thy-roxine(T4 ) ,free triiodothyronine(FT3 ) and free thyroxine(FT4 ) in healthy people aged between 18 and 60 years old in Haikou are-a .Methods According to the recommendations of clinical and laboratory standards institute(CLSI)C28-A3 document ,401 persons aged between 18 and 60 years old were recruited from Haikou(275 male ,126 female) .The makers were analyzed by gender .Estab-lished the reference intervals of TSH ,T3 ,T4 ,FT3 and FT4 in Haikou area .Results Reference intervals based on gender were estab-lished as TSH(0 .58-4 .60 mIU/L) ,T3 (1 .11-2 .31 nmol/L for male ,0 .97-2 .13 nmol/L for female) ,T4 (72 .24-152 .22 nmol/L ) ,FT3 (4 .17-6 .33 pmol/L for male ,3 .95-5 .47 pmol/L for female) ,FT4 (13 .16-21 .29 pmol/L for male ,12 .13-19 .61 pmol/L for female) .Conclusion This study has established the reference intervals of TSH ,T3 ,T4 ,FT3 and FT4 in healthy people aged between 18 and 60 years old in Haikou area .%目的：建立海口地区18～60岁健康人群血清促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）的参考区间。方法按照美国临床实验室标准化协会（CLSI）C28-A3文件，筛选出海口地区18～60岁健康人群401例（男性275例，女性126例，年龄18～60岁），按性别分组分析，建立甲状腺激素的参考区间。结果海口地区18～60岁健康人群的参考区间分别为，TSH ：0．58～4．60 mIU/L ；T3：1．11～2．31 nmol/L （男性），0．97～2．13 nmol/L （女性）；T4：72．24～152．22 nmol/L ；FT3：4．17～6．33 pmol/L （男性），3．95～5．47 pmol/L （女性）；FT4：13．16～21．29 pmol/L （男性），12．13～19．61 pmol/L （女性）。结论本研究建立了海口地区18～60岁健康人群甲状腺激素的参考区间，可供临床参考。