四川地区部分健康人群血清甲状腺激素参考区间的调查

摘要

Objective To preliminarily investigate the reference intervals of serum triiodothyronine (TT3) , thyroxine(TT4) ,free triiodothyronine(FT3) ,free thyroxine(FT4) and thyroid-stimulating hormone(TSH ) among partial healthy population in Sichuan area .Methods According to the screening requirements for laboratory support for the diagnosis and monitoring of thyroid diseases in the National Academy of Clinical Biochemistry(NACB) labo-ratory medicine practice guidelines ,716 apparently healthy individuals with normal physical examination and related laboratory detections were screened out from Sichuan area ,including 421 males and 295 females ,aged 18 - 65 years old .Fasting serum was collected for detecting TT3 ,TT4 ,FT3 ,FT4 and TSH by using the American Abbott i2000 automatic chemiluminescent analyzer .The levels of above indicators were compared between different genders and a-mong different age groups .Results The levels of TT3 ,TT4 ,FT3 ,FT4 and TSH in the male group were (1 .92 ± 0 .28)nmol/L ,(87 .65 ± 15 .89)nmol/L ,(5 .21 ± 0 .58)pmol/L ,(13 .73 ± 1 .70)pmol/L ,(2 .49 ± 1 .45)mU /L ,respec-tively ,while which in the female group were (1 .87 ± 0 .38)nmol/L ,(92 .36 ± 16 .38)nmol/L ,(5 .07 ± 1 .12)pmol/L , (13 .97 ± 2 .10)pmol/L ,(3 .02 ± 2 .05)mU /L ,respectively ,the TT4 and TSH levels had statistically significant difference between different genders (t1 = 3 .42 、t2 = 2 .72 ,P < 0 .05) .The correlation analysis results showed that TT3 and FT3 were negatively correlated with age(r1 = - 0 .12 ,r2 = - 0 .24 ,all P< 0 .05) .T T3 ,TT4 ,FT3 ,FT4 and TSH reference intervals were (1 .26 - 2 .54)nmol/L ,(50 .38 - 119 .63)nmol/L ,(3 .73 - 6 .63)pmol/L ,(10 .41 -17 .33)pmol/L and (0 .38 - 5 .34)mU /L respectively .Conclusion Serum thyroid hormone levels in Sichuan area have differences with the reference intervals provide by the imported reagent kits ,therefore establishing the thyroid hor-mones reference intervals in Sichuan area has an important significance .%目的：初步调查四川地区部分健康人群血清总三碘甲状腺原氨酸（TT3）、总甲状腺素（T T4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（F4）、促甲状腺激素（TSH）的参考区间。方法按照美国国家临床生化学院检验医学应用准则中关于甲状腺疾病诊断与监测的实验室支持中的筛选要求，在四川地区筛选体格检查和相关实验室检查均正常的表面健康人群716例，其中男421例，女295例，年龄18～65岁。采集受检者空腹血清，使用美国雅培 i2000全自动化学发光分析仪进行 TT3、T T4、FT3、FT4、TSH 的检测，比较不同性别、不同年龄间上述各种甲状腺激素水平。结果男性组 TT3、TT4、FT3、FT4、TSH 水平分别为（1．92±0．28）nmol／L 、（87．65±15．89） nmol／L 、（5．21±0．58）pmol／L 、（13．73±1．70）pmoL／L 、（2．49±1．45）mU ／L ，女性组分别为（1．87±0．38）nmol／L 、（92．36±16．38）nmol／L 、（5．07±1．12）pmol／L 、（13．97±2．10）pmol／L 、（3．02±2．05）mU ／L ，T4、TSH 性别间差异有统计学意义（t1＝3．42、t2＝2．72，均 P ＜0．05）；相关分析结果表明，T3、F3与年龄呈负相关（r1＝-0．12、r2＝-0．24，均 P＜0．05）。 TT3、TT4、FT3、FT4、TSH 参考区间分别为（1．26～2．54）nmol／L 、（50．38～119．63） nmol／L 、（3．73～6．63）pmol／L 、（10．41～17．33）pmol／L 、（0．38～5．34）mU ／L 。结论四川地区人群血清甲状腺激素水平与进口试剂盒给定的参考区间有差异，建立四川地区甲状腺激素参考区间具有重要意义。